ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

Base Information

Chemical Name:ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate
CAS No.:862374-45-6
Molecular Formula:C₃₁H₂₇F₃N₂O₆
Molecular Weight:580.56
Hs Code.:

Synonyms:ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

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Chemical Property of ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

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Technology Process of ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

There total 9 articles about ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 862374-54-7
5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

: 623-50-7
ethyl 2-hydroxyacetate

: 862374-45-6
ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm050205o

Reference yield:

: 448957-15-1
3-(allyloxy)-4-fluorophenol

: 862374-45-6
ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / K₂CO₃ / dimethylformamide / 14 h / 100 °C

2.1: AcOH / CH₂Cl₂ / 4 h / 20 °C

2.2: 88 percent / Na(OAc)3BH / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / diisopropylethylamine / dimethylformamide / 18 h / 100 °C

4.1: 92 percent / Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 2 h / 20 °C

5.1: 72 percent / PPh₃; di-tert-butyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; phenylsilane; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;
DOI:10.1021/jm050205o

Reference yield:

: 862374-44-5
4-(3-(allyloxy)-4-fluorophenoxy)benzaldehyde

: 862374-45-6
ethyl (5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AcOH / CH₂Cl₂ / 4 h / 20 °C

1.2: 88 percent / Na(OAc)3BH / CH₂Cl₂ / 12 h / 20 °C

2.1: 100 percent / diisopropylethylamine / dimethylformamide / 18 h / 100 °C

3.1: 92 percent / Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 2 h / 20 °C

4.1: 72 percent / PPh₃; di-tert-butyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; phenylsilane; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;
DOI:10.1021/jm050205o