(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

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Chemical Name:(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester
CAS No.:178430-86-9
Molecular Formula:C₃₅H₃₈N₄O₈
Molecular Weight:642.709
Hs Code.:

Synonyms:(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

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Chemical Property of (S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

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Technology Process of (S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

There total 1 articles about (S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15160-31-3
(tert-butyloxycarbonyl)-l-tryptophan p-nitrophenyl ester

: (S)-2-((S)-2-Amino-2-phenyl-acetylamino)-succinic acid 4-benzyl ester; compound with trifluoro-acetic acid

: 178430-86-9
(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; Yield given; Ambient temperature;
DOI:10.1016/0968-0896(96)00050-8

Reference yield: 92.0%

: (S)-2-Amino-N,N-diethyl-3-naphthalen-1-yl-propionamide; compound with trifluoro-acetic acid

: 178430-86-9
(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

: (S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-N-((S)-1-diethylcarbamoyl-2-naphthalen-1-yl-ethyl)-succinamic acid benzyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/0968-0896(96)00050-8

Reference yield:

: 178430-86-9
(S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-succinic acid 4-benzyl ester

: (S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-2-phenyl-acetylamino}-N-((S)-1-dimethylcarbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: DIEA, BOP / dimethylformamide / 0 - 20 °C

2: H₂ / 10percent Pd/C / methanol / 10 h / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00050-8