methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

Base Information

Chemical Name:methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate
CAS No.:1221821-87-9
Molecular Formula:C₁₆H₁₅F₂N₃O₂
Molecular Weight:319.311
Hs Code.:

Synonyms:methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

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Technology Process of methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

There total 1 articles about methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1120-95-2
3-chloropyridazine

: 923948-65-6
(3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid methyl ester

: 1221821-87-9
methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; Inert atmosphere;
DOI:10.1021/jm9017866

Reference yield: 97.0%

: 1221821-87-9
methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

: 923948-68-9
(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In water;
DOI:10.1021/jm9017866