(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

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Chemical Name:(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride
CAS No.:923948-68-9
Molecular Formula:C₁₅H₁₃F₂N₃O₂*ClH
Molecular Weight:341.745
Hs Code.:

Synonyms:(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

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Chemical Property of (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

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Technology Process of (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

There total 3 articles about (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1221821-87-9
methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate

: 923948-68-9
(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: methyl (3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In water;
DOI:10.1021/jm9017866

Reference yield: 62.0%

: 923948-67-8
lithium (3S,4R)-1-(6-chloropyridazin-3-yl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

: 923948-68-9
(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: lithium (3S,4R)-1-(6-chloropyridazin-3-yl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate; With 2,5-dihydrotoluene; palladium 10% on activated carbon; In ethanol; for 4h; Heating / reflux;

With hydrogenchloride; In diethyl ether; water; acetone;