N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Base Information

Chemical Name:N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride
CAS No.:1372180-01-2
Molecular Formula:C₁₁H₁₅Cl₂N₃O₃S*ClH
Molecular Weight:376.691
Hs Code.:

Synonyms:N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

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Chemical Property of N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Chemical Property:

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Technology Process of N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

There total 13 articles about N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-06-8
tert-butyl (6R,7S)-6-{[(tert-butoxycarbonyl)sulfamoyl]amino}-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372180-01-2
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃; for 2h;

Reference yield:

: (1RS,2SR)-3-(benzylamino)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-(3,4-dichlorophenyl)propan-1-ol

: 1372180-01-2
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

2.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

3.2: 2 h / -78 - 35 °C

4.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

4.2: 18 h / 80 °C

4.3: 2 h / 35 °C / Cooling with ice

5.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

6.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice

7.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

8.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

8.2: 2 h / 90 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

10.1: acetonitrile / 10 - 35 °C

11.1: hydrogenchloride / ethyl acetate / 2 h / 10 - 35 °C

With hydrogenchloride; aluminum (III) chloride; sodium chlorite; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; Dess-Martin periodane; triethylamine; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 8.1: Curtius Rearrangement;

Reference yield:

: methyl 2-[(3,4-dichlorophenyl)(hydroxy)methyl]prop-2-enoate

: 1372180-01-2
N-[(6R,7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]sulfamide monohydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1.1: triethylamine / methanol / 72 h / 10 - 35 °C

2.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

2.2: 0.5 h

3.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

4.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

5.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

6.2: 2 h / -78 - 35 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

7.2: 18 h / 80 °C

7.3: 2 h / 35 °C / Cooling with ice

8.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

9.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice

10.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

11.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 90 °C

11.2: 2 h / 90 °C

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 50 °C

13.1: acetonitrile / 10 - 35 °C

14.1: hydrogenchloride / ethyl acetate / 2 h / 10 - 35 °C

With 1H-imidazole; hydrogenchloride; aluminum (III) chloride; sodium chlorite; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; Dess-Martin periodane; triethylamine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; 11.1: Curtius Rearrangement;