(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

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Chemical Name:(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine
CAS No.:1433607-76-1
Molecular Formula:C₃₁H₃₇FN₆O₃
Molecular Weight:560.672
Hs Code.:

Synonyms:(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

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Chemical Property of (2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

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Technology Process of (2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

There total 3 articles about (2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 132482-08-7
(R)-N-Boc-2-(2-(methylsulphonyloxy)ethyl)pyrrolidine

: 1433605-21-0
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 1433607-76-1
(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

Guidance literature:: (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

(R)-N-Boc-2-(2-(methylsulphonyloxy)ethyl)pyrrolidine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 132482-06-5,220312-34-5
tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

: 1433607-76-1
(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

2.2: 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 101555-60-6
2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1433607-76-1
(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

1.2: 1 h / Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

3.2: 20 °C

With 4-methyl-morpholine; sodium hydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;