tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate
• CAS No.: 132482-06-5
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.293
• European Community (EC) Number: 840-881-6
• Nikkaji Number: J1.177.525J
• Mol file: 132482-06-5.mol

Synonyms:132482-06-5;tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate;(R)-1-BOC-2-(2-HYDROXYETHYL)PYRROLIDINE;(R)-tert-Butyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate;SCHEMBL3420227;MXPOLUPSEVGAAS-SECBINFHSA-N;AMY35426;MFCD20270013;AKOS025404656;AS-51467;(2R)-1-Boc-2-(2-hydroxyethyl)pyrrolidine;(2S)-1-Boc-2-(2-hydroxyethyl)pyrrolidine;CS-0048661;P12743;EN300-1178683;A888287;(R)-tert-Butyl2-(2-hydroxyethyl)pyrrolidine-1-carboxylate;tert-butyl(2R)-2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate;(2R)-2-(2-Hydroxyethyl)pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-2-(2-Hydroxy-ethyl)-pyrrolidine-1-carboxylic acid t-butyl ester;(R)-2-(2-Hydroxy-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-2-(2-Hydroxy-ethyl)-pyrrolidine-1-carboxylic acid, t-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2R)-

Chemical Property of tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 1.70620
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 215.15214353
• Heavy Atom Count: 15
• Complexity: 222

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-1-Boc-2-(2-hydroxyethyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCC1CCO
• Isomeric SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1CCO

Technology Process of tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate

There total 14 articles about tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (101555-60-6) → tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate (132482-06-5,220312-34-5)

Guidance literature:

2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; for 0.333333h; Inert atmosphere; Cooling with ice;

With sodium tetrahydroborate; water; In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield: 98.5%

methyl (R)-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanoate (132482-05-4,813433-68-0) → tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate (132482-06-5,220312-34-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 97.0%

oxirane (75-21-8,99932-75-9) + tert-butyl pyrrolidine-1-carboxylate (86953-79-9) → tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate (132482-06-5,220312-34-5)

Guidance literature:

tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (-)-sparteine; In diethyl ether; at -78 ℃; for 4.16667h;

oxirane; With boron trifluoride diethyl etherate; In diethyl ether; at -78 ℃; for 0.5h;

upstream raw materials:

methyl (R)-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanoate

oxirane

tert-butyl pyrrolidine-1-carboxylate

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde

Downstream raw materials:

(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

SB 269970 A

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(R)-(2-(pyrrolidin-2-yl)ethyl)oxime

(2R)-N-Boc-2-(((2-((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl)pyrrolidine

Refernces

• 1、 -. "Tetrahydropyrido [3, 4-d] pyrimidine derivative and medical application thereof". Paragraph 0587; 0590; 0595-0598. . Retrieved 2021/03/06.
• 2、 -. "(QUINOLINE OR ISOQUINOLINE)SULFONAMIDES OF CYCLIC AMINES AS ANTIPSYCHOTIC DRUGS". Page/Page column 21; 22. . Retrieved 2016/01/25.