1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

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Chemical Name:1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine
CAS No.:1037360-33-0
Molecular Formula:C₁₉H₂₃ClF₃N₅
Molecular Weight:413.873
Hs Code.:

Synonyms:1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

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Chemical Property of 1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

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Technology Process of 1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

There total 6 articles about 1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1037235-28-1
({cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methyl)-carbamic acid tert-butyl ester

: 1037360-33-0
1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 65619-29-6
1-(3-chlorophenyl)-4-oxocyclohexanecarbonitrile

: 1037360-33-0
1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / toluene / 18 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 - 50 °C

3: triethylamine / dichloromethane / 4 h / 20 °C

4: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetic acid / 5 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 887978-99-6
C-[8-(3-chlorophenyl)-1.4-dioxa-spiro[4.5]dec-8-yl]methylamine

: 1037360-33-0
1-{cis-1-(3-chlorophenyl)-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]cyclohexyl}methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: pyridinium p-toluenesulfonate / acetone; water / 48 h / Reflux

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetic acid / 5 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.bmcl.2013.12.118