2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

Base Information

• Chemical Name: 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride
• CAS No.: 1268343-96-9
• Molecular Formula: C₁₅H₂₁ClO₄S
• Molecular Weight: 332.848
• Mol file: 1268343-96-9.mol

Synonyms:2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

Chemical Property of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

There total 3 articles about 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.7%

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt (126962-22-9) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride (1268343-96-9)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

DOI:10.1021/jm101403g

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride (1268343-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 25 °C

2: pyridine / 4 h / 130 °C / Inert atmosphere

3: thionyl chloride / N,N-dimethyl-formamide / 1 h / 25 °C

With pyridine; thionyl chloride; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm101403g

Reference yield:

(+/-)-2-(4-isobutylphenyl)propanoyl chloride (71381-91-4,114978-05-1,115588-20-0,34715-60-1) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride (1268343-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / 130 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide / 1 h / 25 °C

With pyridine; thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm101403g

upstream raw materials:

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

ibuprofen

(+/-)-2-(4-isobutylphenyl)propanoyl chloride

Downstream raw materials:

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

N-methoxyl 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylamide