2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

Base Information

• Chemical Name: 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid
• CAS No.: 1268344-00-8
• Molecular Formula: C₁₅H₂₃NO₅S
• Molecular Weight: 329.417
• Mol file: 1268344-00-8.mol

Synonyms:2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

Chemical Property of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

There total 4 articles about 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride (1268343-96-9) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid (1268344-00-8)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; at 25 ℃; for 2h;

DOI:10.1021/jm101403g

Reference yield:

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt (126962-22-9) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid (1268344-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 1 h / 25 °C

2: hydroxylamine hydrochloride; potassium carbonate / tetrahydrofuran / 2 h / 25 °C

With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm101403g

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid (1268344-00-8)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 25 °C

2: pyridine / 4 h / 130 °C / Inert atmosphere

3: thionyl chloride / N,N-dimethyl-formamide / 1 h / 25 °C

4: hydroxylamine hydrochloride; potassium carbonate / tetrahydrofuran / 2 h / 25 °C

With pyridine; thionyl chloride; oxalyl dichloride; hydroxylamine hydrochloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm101403g

upstream raw materials:

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

ibuprofen

(+/-)-2-(4-isobutylphenyl)propanoyl chloride