ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

Base Information

Chemical Name:ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate
CAS No.:1312009-61-2
Molecular Formula:C₂₇H₂₉N₅O₄
Molecular Weight:487.558
Hs Code.:

Synonyms:ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

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Chemical Property of ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

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Technology Process of ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

There total 20 articles about ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1312008-95-9
ethyl 4-{6-ethyl-5-[(hydroxyamino)(imino)methyl]-1H-indazol-1-yl}butanoate

: 1312009-61-2
ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

Guidance literature:: 3-cyano-4-isopropoxybenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

ethyl 4-{6-ethyl-5-[(hydroxyamino)(imino)methyl]-1H-indazol-1-yl}butanoate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

Reference yield:

: 15126-06-4
methyl 3-iodo-4-hydroxybenzoate

: 1312009-61-2
ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 18 h / 80 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; sodium cyanide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1312009-61-2
ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Iodine monochloride; acetic acid / 20 - 65 °C

2.1: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 18 h / 80 °C

With Iodine monochloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; sodium cyanide; In methanol; N,N-dimethyl-formamide;