4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

Base Information

Chemical Name:4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid
CAS No.:1312009-60-1
Molecular Formula:C₂₅H₂₅N₅O₄
Molecular Weight:459.505
Hs Code.:

Synonyms:4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

There total 20 articles about 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312009-61-2
ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate

: 1312009-60-1
4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

Guidance literature:: ethyl 4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; isopropyl alcohol; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 15126-06-4
methyl 3-iodo-4-hydroxybenzoate

: 1312009-60-1
4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 18 h / 80 °C

5.1: sodium hydroxide; water / isopropyl alcohol; tetrahydrofuran; methanol / 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; sodium cyanide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1312009-60-1
4-[5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-6-ethyl-1H-indazol-1-yl]butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Iodine monochloride; acetic acid / 20 - 65 °C

2.1: sodium cyanide / N,N-dimethyl-formamide / 24 h / 120 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 18 h / 80 °C

6.1: sodium hydroxide; water / isopropyl alcohol; tetrahydrofuran; methanol / 20 °C

With water; Iodine monochloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; sodium cyanide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;