(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Base Information

Chemical Name:(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate
CAS No.:278595-39-4
Molecular Formula:C₃₅H₄₃NO₃
Molecular Weight:525.731
Hs Code.:

Synonyms:(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Suppliers and Price of (1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

There total 8 articles about (1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 513-38-2
Isobutyl iodide

: 278595-59-8
(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-(Z)-dehydrobutyrinate

: 278595-39-4
(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Guidance literature:: With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃;
DOI:10.1021/jo9918091

Reference yield:

: 105970-13-6
(1R,2S,5R)-8-(β-naphthyl)menthol

: 278595-39-4
(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / p-TsOH / benzene / Heating

2: 81 percent / LDA; n-BuLi / hexamethylphosphoric acid triamide; hexane; tetrahydrofuran / -78 °C

With n-butyllithium; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; benzene; 1: Esterification / 2: Alkylation;
DOI:10.1021/jo9918091

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 278595-39-4
(1'R,2'S,5'R)-8'-(β-naphthyl)menthyl N-benzoyl-L-α-vinylleucinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaBH₄ / dimethylformamide / 1 h / 100 °C

1.2: 88 percent / ethyl acetate; hexane

2.1: 90 percent / O₃ / benzene; CH₂Cl₂; various solvent(s) / 1 h / Heating

3.1: 96 percent / TFA; anisole / CH₂Cl₂ / 3 h / 20 °C

4.1: 64 percent / p-TsOH / benzene / Heating

5.1: 81 percent / LDA; n-BuLi / hexamethylphosphoric acid triamide; hexane; tetrahydrofuran / -78 °C

With sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; ozone; methoxybenzene; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Ring cleavage / 1.2: Esterification / 2.1: ozonolysis / 3.1: Hydrolysis / 4.1: Esterification / 5.1: Alkylation;
DOI:10.1021/jo9918091