N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

Base Information

Chemical Name:N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester
CAS No.:1612798-72-7
Molecular Formula:C₂₅H₃₆INO₇
Molecular Weight:589.468
Hs Code.:

Synonyms:N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

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Chemical Property of N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

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Technology Process of N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

There total 3 articles about N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1612798-71-6
N-(tert-butylcarbonyl)-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

: 1612798-72-7
N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

Guidance literature:: With iodine; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1021/ol501243g

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 1612798-72-7
N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 22 h / 50 °C

2: pyridine / 20 h / 20 °C

3: iodine; bis-[(trifluoroacetoxy)iodo]benzene / dichloromethane / 20 °C / Cooling with ice

With pyridine; thionyl chloride; iodine; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane;
DOI:10.1021/ol501243g

Reference yield:

: 1421-65-4
L-dopa methyl ester hydrochloride

: 1612798-72-7
N-(tert-butylcarbonyl)-2-iodo-3,4-di(tertbutylcarbonyl)-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 20 h / 20 °C

2: iodine; bis-[(trifluoroacetoxy)iodo]benzene / dichloromethane / 20 °C / Cooling with ice

With pyridine; iodine; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane;
DOI:10.1021/ol501243g