N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS No.:1269116-61-1
Molecular Formula:C₂₆H₂₈F₃N₅O₆
Molecular Weight:563.533
Hs Code.:

N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Synonyms:N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Technology Process of N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

There total 9 articles about N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1269118-00-4
N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

: 70-11-1
α-bromoacetophenone

: 1269116-61-1
N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: With potassium carbonate; lithium bromide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 10 - 50 ℃;

Reference yield:

: 1194-22-5
2-methyl-4,6-dihydroxypyrimidine

: 1269116-61-1
N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 11 h / 10 - 120 °C

2.1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol / 1 h / 10 - 35 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 10 - 35 °C

4.1: triethylamine / 1 h / 0 - 35 °C

5.1: triethylamine / tetrahydrofuran / 3 h / 10 - 35 °C

5.2: 2 h / 10 - 35 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 - 35 °C

7.1: sodium hydroxide; water / ethanol; tetrahydrofuran; 2-methoxy-ethanol / 80 - 100 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 10 - 35 °C

9.1: potassium carbonate; lithium bromide / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 10 - 50 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium bromide; sodium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 14160-91-9
4,6-dichloro-2-methyl-pyrimidine-5-carbaldehyde

: 1269116-61-1
N-[1-(hydroxyacetyl)piperidin-4-yl]-2,7-dimethyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol / 1 h / 10 - 35 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 10 - 35 °C

3.1: triethylamine / 1 h / 0 - 35 °C

4.1: triethylamine / tetrahydrofuran / 3 h / 10 - 35 °C

4.2: 2 h / 10 - 35 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 10 - 35 °C

6.1: sodium hydroxide; water / ethanol; tetrahydrofuran; 2-methoxy-ethanol / 80 - 100 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 10 - 35 °C

8.1: potassium carbonate; lithium bromide / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 10 - 50 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium bromide; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;