2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Base Information

Chemical Name:2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride
CAS No.:1243257-39-7
Molecular Formula:C₃₆H₃₄Cl₂N₂O₆*ClH
Molecular Weight:698.043
Hs Code.:

Synonyms:2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

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Chemical Property of 2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

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Technology Process of 2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

There total 5 articles about 2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1160554-08-4
C₁₇H₂₀ClNO₃

: 20357-37-3
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride

: 1243257-39-7
2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Guidance literature:: C₁₇H₂₀ClNO₃; 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In diethyl ether;
DOI:10.1002/cjoc.201200196

Reference yield:

: 13101-93-4
1-(5-chloro-6-methoxynaphthalen-2-yl)ethan-1-one

: 1243257-39-7
2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide / ethanol / 6 h / Reflux

2: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C

3: formic acid / 18 h / 180 °C

4: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; copper(ll) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; 3: Leuckart-Wallach reaction;
DOI:10.1002/cjoc.201200196

Reference yield:

: C₁₇H₂₁BrClNO₄

: 1243257-39-7
2-[2-(6-methoxy-5-chloronaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / 18 h / 180 °C

2: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; In tetrahydrofuran; 1: Leuckart-Wallach reaction;
DOI:10.1002/cjoc.201200196