(R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol

Base Information

• Chemical Name: (R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol
• CAS No.: 147622-51-3
• Molecular Formula: C₁₃H₂₀O₃Si
• Molecular Weight: 252.386
• Mol file: 147622-51-3.mol

Synonyms:(R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol

Chemical Property of (R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol

There total 1 articles about (R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

E-(1R*)-1-(4-methoxyphenyl)-3-trimethylsilyl-2-propen-1-ol (163748-62-7) → (R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol (147622-51-3) + E-(1S)-1-(4-methoxyphenyl)-3-trimethylsilyl-2-propen-1-ol + (S)-(4-Methoxy-phenyl)-((2S,3S)-3-trimethylsilanyl-oxiranyl)-methanol

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; (-)-diisopropyl tartrate; In dichloromethane; toluene; at -20 ℃; for 13.5h; Yield given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)80702-X

Reference yield:

(R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol (147622-51-3) → 3-(3,5-dimethoxyphenoxy)-3-(4-methoxyphenyl)prop-2-en-1-ol

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

2: 99 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran

3: 75 percent / n-BuLi, MgBr₂ / tetrahydrofuran; hexane

With n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; magnesium bromide; In tetrahydrofuran; hexane;

DOI:10.1016/S0040-4020(01)80702-X

Reference yield:

(R)-(4-Methoxy-phenyl)-((2R,3R)-3-trimethylsilanyl-oxiranyl)-methanol (147622-51-3) → (1R,2S)-1-(2,6-diiodo-3,5-dimethoxyphenoxy)-1-(4-methoxyphenyl)-2,3-epoxypropane

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

2: 99 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)80702-X

upstream raw materials:

E-(1R*)-1-(4-methoxyphenyl)-3-trimethylsilyl-2-propen-1-ol

Downstream raw materials:

(1R,2R,3R)-1-(2,6-diiodo-3,5-dimethoxyphenoxy)-1-(4-methoxyphenyl)-3-trimethylsilyl-2,3-epoxypropane

(1S,2R,3R)-1-(2,6-diiodo-3,5-dimethoxyphenoxy)-1-(4-methoxyphenyl)-3-trimethylsilyl-2,3-epoxypropane