(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Base Information

Chemical Name:(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol
CAS No.:179943-95-4
Molecular Formula:C₃₁H₅₀O₃Si₂
Molecular Weight:526.907
Hs Code.:

Synonyms:(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Suppliers and Price of (E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

There total 6 articles about (E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 179943-79-4
(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

: 179943-95-4
(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 3h;
DOI:10.1021/ja9607796

Reference yield:

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 179943-95-4
(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / 2,4-lutidine / CH₂Cl₂ / 0.42 h / -78 - 0 °C

2: 84 percent / DIBAL-H / CH₂Cl₂; tetrahydrofuran / 3 h / -78 °C

With 2,4-lutidine; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja9607796

Reference yield:

: 167468-64-6
(2R)-2-(tert-butyldiphenylsiloxy)propanal

: 179943-95-4
(E)-(4R,5S,6R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-5-triethylsilanyloxy-hept-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) molecular sieves 4A, 2.) 1 M NaOH / 1.) toluene, -78 deg C, 1.5 h, 2.) toluene, RT, 3 h

2: 1.) O₃/O₂, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, 2 h

3: CH₂Cl₂ / 26 h / 50 °C

4: 99 percent / 2,4-lutidine / CH₂Cl₂ / 0.42 h / -78 - 0 °C

5: 84 percent / DIBAL-H / CH₂Cl₂; tetrahydrofuran / 3 h / -78 °C

With sodium hydroxide; 2,4-lutidine; 4 A molecular sieve; oxygen; diisobutylaluminium hydride; ozone; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja9607796