4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Base Information

• Chemical Name: 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
• CAS No.: 808762-62-1
• Molecular Formula: C₁₇H₁₃BrFN₃O₃
• Molecular Weight: 406.211
• Mol file: 808762-62-1.mol

Synonyms:4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Chemical Property of 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

There total 10 articles about 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

4-bromo-2-fluoroaniline (367-24-8) + 6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (808762-62-1)

Guidance literature:

In isopropyl alcohol; at 83 ℃;

Reference yield: 82.0%

C11H11ClN2O3 (948551-62-0) + 4-bromo-2-fluoroaniline (367-24-8) → 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (808762-62-1)

Guidance literature:

In isopropyl alcohol; at 110 ℃; for 3h;

Reference yield:

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (179688-53-0) → 4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (808762-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

2: isopropyl alcohol / 83 °C

With thionyl chloride; In N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

C₁₁H₁₁ClN₂O₃

4-bromo-2-fluoroaniline

6-acetoxy-4-chloro-7-methoxyquinazoline

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

Downstream raw materials:

N-(4-bromo-2-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine

N-(4-bromo-2-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrol-6(3H)-yl)propoxy)quinazolin-4-amine

tert-butyl 5-(3-((4-((4-bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

N-(4-bromo-2-fluorophenyl)-6-(3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine