7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

Base Information

Chemical Name:7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime
CAS No.:333421-29-7
Molecular Formula:C₂₀H₂₁N₅O₁₁S₂
Molecular Weight:571.546
Hs Code.:

Synonyms:7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

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Chemical Property of 7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

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Technology Process of 7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

There total 6 articles about 7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 333421-23-1
7,11-di(4-nitrobenzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4,7]dodecan-9-one

: 333421-29-7
7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; Heating;
DOI:10.1016/S0040-4039(01)00260-X

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 333421-29-7
7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / K₂CO₃ / tetrahydrofuran; H₂O / 20 °C

2.1: 91 percent / CrO₃; H₂SO₄ / acetone / 20 °C

3.1: 90 percent / p-TsOH / toluene

4.1: 76 percent / K₂CO₃ / acetone / Heating

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: 95 percent / Me₂S

6.1: 91 percent / NH₂OH*HCl; NaOAc / ethanol / Heating

With chromium(VI) oxide; sulfuric acid; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; ozone; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)00260-X

Reference yield:

: 333421-07-1
1,3-di(4-nitrobenzenesulfonamido)propanol

: 333421-29-7
7,11-bis-(4-nitro-benzenesulfonyl)-1,4-dioxa-7,11-diaza-spiro[4.7]dodecan-9-one oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / CrO₃; H₂SO₄ / acetone / 20 °C

2.1: 90 percent / p-TsOH / toluene

3.1: 76 percent / K₂CO₃ / acetone / Heating

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: 95 percent / Me₂S

5.1: 91 percent / NH₂OH*HCl; NaOAc / ethanol / Heating

With chromium(VI) oxide; sulfuric acid; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; ozone; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(01)00260-X