3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid

Base Information

• Chemical Name: 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid
• CAS No.: 68898-85-1
• Molecular Formula: C₂₂H₃₄N₂O₆
• Molecular Weight: 422.522

Synonyms:3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid

Chemical Property of 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid

Chemical Property:

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Technology Process of 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid

There total 4 articles about 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester (68914-45-4) → 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid (68898-85-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 1913.4 Torr;

DOI:10.1021/ja00494a030

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid (68898-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) ClCO₂iBu, 4-methyl-morpholine, THF, (ii) /BRN= 3627058/, Et₃N, DMF

2: 4-methyl-morpholine / tetrahydrofuran / Ambient temperature

3: H₂ / Pd-C / ethanol / 1913.4 Torr

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/ja00494a030

Reference yield:

tyramine hydrochloride (60-19-5) → 3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid (68898-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) ClCO₂iBu, 4-methyl-morpholine, THF, (ii) /BRN= 3627058/, Et₃N, DMF

2: 4-methyl-morpholine / tetrahydrofuran / Ambient temperature

3: H₂ / Pd-C / ethanol / 1913.4 Torr

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/ja00494a030

upstream raw materials:

(E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester

N-tert-butoxycarbonyl-L-leucine

tyramine hydrochloride

{(S)-1-[2-(4-Hydroxy-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

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