(E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester

Base Information

• Chemical Name: (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester
• CAS No.: 68914-45-4
• Molecular Formula: C₂₉H₃₈N₂O₆
• Molecular Weight: 510.631

Synonyms:(E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester

Chemical Property of (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester

There total 3 articles about (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester (68914-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) ClCO₂iBu, 4-methyl-morpholine, THF, (ii) /BRN= 3627058/, Et₃N, DMF

2: 4-methyl-morpholine / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1021/ja00494a030

Reference yield:

tyramine hydrochloride (60-19-5) → (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester (68914-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) ClCO₂iBu, 4-methyl-morpholine, THF, (ii) /BRN= 3627058/, Et₃N, DMF

2: 4-methyl-morpholine / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1021/ja00494a030

Reference yield:

benzyl prop-2-ynoate (14447-01-9) + {(S)-1-[2-(4-Hydroxy-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester (68898-80-6) → (E)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-acrylic acid benzyl ester (68914-45-4)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/ja00494a030

upstream raw materials:

benzyl prop-2-ynoate

{(S)-1-[2-(4-Hydroxy-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

N-tert-butoxycarbonyl-L-leucine

tyramine hydrochloride

Downstream raw materials:

3-{4-[2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-ethyl]-phenoxy}-propionic acid

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