2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Base Information

Chemical Name:2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid
CAS No.:198781-81-6
Molecular Formula:C₂₀H₃₂N₂O₆
Molecular Weight:396.484
Hs Code.:

2-[2-(2-<i>tert</i>-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Synonyms:2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

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Chemical Property of 2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

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Technology Process of 2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

There total 15 articles about 2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 358365-66-9
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

: 198781-81-6
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0040-4039(01)00747-X

Reference yield:

: 554-84-7
meta-nitrophenol

: 198781-81-6
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 98 percent / K₂CO₃ / acetone / Heating

2.1: 1,2-dichloro-benzene / 6 h / 150 °C

3.1: 87 percent / K₂CO₃ / acetone

4.1: Hg(NO₃)2 / CH₂Cl₂ / 24 h / Heating

4.2: aq. NaCl / 3 h / 20 °C

4.3: NaBH₄; O₂ / dimethylformamide

5.1: 85 percent / H₂ / Pd/C / ethanol

6.1: 74 percent / 2,6-lutidine / 1,2-dichloro-ethane

7.1: 100 percent / H₂ / Pd/C / ethanol

With 2,6-dimethylpyridine; hydrogen; potassium carbonate; mercury(II) nitrate; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; 1,2-dichloro-benzene; acetone; 2.1: Claisen rearrangement;
DOI:10.1016/S0040-4039(01)00747-X

Reference yield:

: 58621-42-4
2-allyl-1-hydroxy-3-nitrobenzene

: 198781-81-6
2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 87 percent / K₂CO₃ / acetone

2.1: Hg(NO₃)2 / CH₂Cl₂ / 24 h / Heating

2.2: aq. NaCl / 3 h / 20 °C

2.3: NaBH₄; O₂ / dimethylformamide

3.1: 85 percent / H₂ / Pd/C / ethanol

4.1: 74 percent / 2,6-lutidine / 1,2-dichloro-ethane

5.1: 100 percent / H₂ / Pd/C / ethanol

With 2,6-dimethylpyridine; hydrogen; potassium carbonate; mercury(II) nitrate; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1016/S0040-4039(01)00747-X