358365-66-9

Upstream product

• 131423-64-8 benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate 
• 331819-82-0 [2-(2-amino-6-methoxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester 
• 358365-65-8 [2-(2-amino-6-methoxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester 
• 19689-86-2 2-nitro-6-methoxybenzyl bromide 
• 331819-80-8 [1-hydroxymethyl-2-(2-methoxy-6-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 331819-79-5 2-amino-3-(2-methoxy-6-nitro-phenyl)-propionic acid tert-butyl ester 
• 19689-87-3 (2-methoxy-6-nitrophenyl)methanol 
• 50603-42-4 5-nitro-1,3-benzodioxane 
• 57356-31-7 2-(hydroxymethyl)-3-nitrophenol 
• 198781-76-9 [1-hydroxymethyl-2-(2-methoxy-6-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 137898-16-9 2-allyl-3-methoxynitrobenzene 
• 58621-55-9 1-allyloxy-3-nitro-benzene 
• 58621-42-4 2-allyl-1-hydroxy-3-nitrobenzene 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 198781-81-6 2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid 

Relevant academic research and scientific papers

Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C

7-methoxy-8-decynyl-benzolactam-V8 4 is synthesized using a catalytic asymmetric alkylation reaction as a key step. This compound shows potent activity to three PKC isozymes tested (Ki = 45.6, 91.1, and 121.3 nM to PKCα, δ, and ε, respectively), indicating that introduction of a suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity.

Synthesis of 7-methoxybenzolactam-V8 using aminomercuration as a key reaction

7-Methoxybenzolactam-V8 was synthesized using a short synthetic route that employs aminomercuration as a key reaction.