N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

Base Information

Chemical Name:N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid
CAS No.:80014-97-7
Molecular Formula:C₂₃H₂₁N₅O₆
Molecular Weight:463.45
Hs Code.:

N-<4-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-aspartic acid

Synonyms:N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

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Technology Process of N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

There total 5 articles about N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 80014-78-4
diethyl N-<4-prop-2-ynylamino>benzoyl>-L-aspartate

: 80014-97-7
N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 18h; Ambient temperature;
DOI:10.1021/jm00156a033

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 80014-97-7
N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / pyridine / toluene / 1.) 0 deg C, 30 min, 2.) RT, 1 h

2: 97 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 52 percent / 2,6-lutidine / various solvent(s) / 48 h / Ambient temperature

4: 48 percent / CaCO₃ / various solvent(s) / 96 h / Ambient temperature

5: 72 percent / 1N NaOH / ethanol / 18 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; sodium hydroxide; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00156a033

Reference yield:

: 27128-94-5
diethyl N-(4-nitrobenzoyl)-L-aspartate

: 80014-97-7
N-<4-prop-2-ynylamino>benzoyl>-L-aspartic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

2: 52 percent / 2,6-lutidine / various solvent(s) / 48 h / Ambient temperature

3: 48 percent / CaCO₃ / various solvent(s) / 96 h / Ambient temperature

4: 72 percent / 1N NaOH / ethanol / 18 h / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00156a033