Technology Process of 1-[3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-carboxyl]-pyrrolidine-2-carboxylic acid
There total 8 articles about 1-[3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-carboxyl]-pyrrolidine-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-[3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-carboxyl]-pyrrolidine-2-carboxylic acid methyl ester;
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 50 ℃;
for 12h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: ethanol / 2 h / Reflux
2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 5 h / 25 °C
3: triethylsilane; trifluoroacetic acid / 4 h / 25 °C
4: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
5: water; sodium hydroxide / tetrahydrofuran; methanol / 6 h / 60 °C
6: triethylamine; HATU / dichloromethane / 12 h / 25 °C
7: water; lithium hydroxide / tetrahydrofuran / 12 h / 50 °C
With
triethylsilane; water; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; lithium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate nonohydrate; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: ethanol / 2 h / Reflux
2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 5 h / 25 °C
3: triethylsilane; trifluoroacetic acid / 4 h / 25 °C
4: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
5: water; sodium hydroxide / tetrahydrofuran; methanol / 6 h / 60 °C
6: triethylamine; HATU / dichloromethane / 12 h / 25 °C
7: water; lithium hydroxide / tetrahydrofuran / 12 h / 50 °C
With
triethylsilane; water; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; lithium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate nonohydrate; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;