Pyrazoloacridine

Base Information

Chemical Name:Pyrazoloacridine
CAS No.:99009-20-8
Molecular Formula:C₁₉H₂₁N₅O₃
Molecular Weight:367.407
Hs Code.:
NSC Number:627168
UNII:L24XJN68OW
DSSTox Substance ID:DTXSID50869326,DTXSID301316714
Nikkaji Number:J343.807D
Wikidata:Q27282607
NCI Thesaurus Code:C1564
Metabolomics Workbench ID:153518
ChEMBL ID:CHEMBL118841
Mol file:99009-20-8.mol

Synonyms:9-methoxy-N,N-dimethyl-5-nitropyrazolo(3,4,5-k)acridine-2(6H)-propanamine;NSC 366140;NSC 366140, methanesulfonate salt;NSC-366140;PD 115934;PD-115934;pyrazoloacridine;pyrazoloacridine mesylate

Suppliers and Price of Pyrazoloacridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE Aldrich
50mg
$ 144.00

ChemScene
Pyrazoloacridine ≥98.0%
5mg
$ 250.00

American Custom Chemicals Corporation
PYRAZOLOACRIDINE 95.00%
5MG
$ 501.64

Total 7 raw suppliers

Chemical Property of Pyrazoloacridine

Chemical Property:

Vapor Pressure:3.74E-14mmHg at 25°C
Boiling Point:595.6°C at 760 mmHg
Flash Point:314°C
PSA：91.90000
Density:1.314g/cm³
LogP:4.06250
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:367.16443955
Heavy Atom Count:27
Complexity:542

Purity/Quality:

98%Min ^*data from raw suppliers

(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE Aldrich ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCCN1C2=C3C(=C(C=C2)[N+](=O)[O-])NC4=C(C3=N1)C=C(C=C4)OC
Recent ClinicalTrials:Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma

Technology Process of Pyrazoloacridine

There total 5 articles about Pyrazoloacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 21814-48-2
1-chloro-7-methoxy-4-nitro-10H-acridin-9-one

: 3762-38-7
3-(dimethylamino)propylhydrazine

: 99009-20-8
Pyrazoloacridine

Guidance literature:: In tetrahydrofuran; methanol; for 7.5h; Ambient temperature;
DOI:10.1021/jm00104a001

Reference yield:

: 55775-97-8
2,6-dichloro-3-nitrobenzoic acid

: 99009-20-8
Pyrazoloacridine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / N,N-dimethylaniline / 18 h / Heating

2: 88 percent / N,N-dimethylaniline, POCl₃ / 1,2-dichloro-ethane / 18 h / Heating

3: 89 percent / tetrahydrofuran; methanol / 7.5 h / Ambient temperature

With N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00104a001

Reference yield:

: 55776-09-5
6-chloro-2-<(4-methoxyphenyl)amino>-3-nitrobenzoic acid

: 99009-20-8
Pyrazoloacridine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / N,N-dimethylaniline, POCl₃ / 1,2-dichloro-ethane / 18 h / Heating

2: 89 percent / tetrahydrofuran; methanol / 7.5 h / Ambient temperature

With N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00104a001