diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

Base Information

Chemical Name:diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine
CAS No.:1330633-27-6
Molecular Formula:C₂₁H₂₉N₄O₆P
Molecular Weight:464.458
Hs Code.:

Synonyms:diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

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Chemical Property of diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

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Technology Process of diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

There total 5 articles about diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1330633-15-2
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-6-chloropurine

: 1330633-27-6
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

Guidance literature:: With water; trifluoroacetic acid;
DOI:10.1016/j.bmc.2011.06.045

Reference yield:

: 1330633-12-9
ethyl 2-(1-(benzyloxy)-3-(diethoxyphosphoryl)propan-2-yloxy)acetate

: 1330633-27-6
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / -20 - 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

3: water; trifluoroacetic acid

With borane-THF; di-isopropyl azodicarboxylate; water; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.06.045

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 1330633-27-6
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]hypoxanthine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - -30 °C / Inert atmosphere

1.3: -30 - 20 °C

2.1: borane-THF / -20 - 20 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

4.1: water; trifluoroacetic acid

With n-butyllithium; borane-THF; di-isopropyl azodicarboxylate; water; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; hexane; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.06.045