methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate

Base Information

• Chemical Name: methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate
• CAS No.: 1345465-86-2
• Molecular Formula: C₁₉H₂₀F₃N₃O₇
• Molecular Weight: 459.379
• Mol file: 1345465-86-2.mol

Synonyms:methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate

Chemical Property of methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate

There total 1 articles about methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 2-[(tert-butoxycarbonyl)amino]-2-(trifluoromethyl)pent-4-ynoate (929616-33-1) + 4-nitrobenzohydroximoyl chloride (1011-84-3) → methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate (1345465-86-2)

Guidance literature:

With copper(ll) sulfate pentahydrate; potassium hydrogencarbonate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; regioselective reaction;

DOI:10.1039/c1ob06040f

Reference yield: 80.0%

methyl 2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate (1345465-86-2) → methyl 2-amino-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate (1345465-95-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.833333h;

DOI:10.1039/c1ob06040f

upstream raw materials:

methyl 2-[(tert-butoxycarbonyl)amino]-2-(trifluoromethyl)pent-4-ynoate

4-nitrobenzohydroximoyl chloride

Downstream raw materials:

methyl 2-amino-3,3,3-trifluoro-2-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}propanoate