(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

Base Information

Chemical Name:(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide
CAS No.:1452467-19-4
Molecular Formula:C₁₄H₁₆N₄O₄
Molecular Weight:304.305
Hs Code.:

Synonyms:(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

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Chemical Property of (2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

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Technology Process of (2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

There total 4 articles about (2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1452467-18-3
(2S,5R)-6-(benzyloxy)-7-oxo-N'-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

: 1452467-19-4
(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; under 517.162 Torr;

Reference yield:

: 613-94-5
benzoic acid hydrazide

: 1452467-19-4
(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 1 h / 20 °C / 517.16 Torr

With dmap; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

Reference yield:

: 1174020-25-7,2064219-13-0
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid

: 1452467-19-4
(2R,5R)-6-hydroxy-7-oxo-N’-(phenylcarbonyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 1 h / 20 °C / 517.16 Torr

With dmap; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;