ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

Base Information

Chemical Name:ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate
CAS No.:869015-34-9
Molecular Formula:C₃₄H₃₆N₂O₅S₃
Molecular Weight:648.868
Hs Code.:

Synonyms:ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

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Chemical Property of ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

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Technology Process of ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

There total 5 articles about ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 869015-32-7
ethyl [4-[3,3-di(5-bromothiophen-2-yl)allylsulfanyl]-2-methylphenoxy]acetate

: 18341-31-6
N-methyl-N-(2-propynyl)acetamide

: 869015-34-9
ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 65 ℃; for 6h; Inert atmosphere;

Reference yield:

: 869015-31-6
3,3-di(5-bromothiophen-2-yl)allyl alcohol

: 869015-34-9
ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / Inert atmosphere; Cooling with ice-water

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.75 h / 20 °C / Inert atmosphere

3: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 6 h / 65 °C / Inert atmosphere

With carbon tetrabromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;

Reference yield:

: 855605-64-0
bis-(5-bromo-thiophen-2-yl)-methanone

: 869015-34-9
ethyl [4-[3,3-bis[5-[3-(N-acetyl-N-methylamino)propynyl]thiophene-2-yl]allylsulfanyl]-2-methylphenoxy]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

1.2: 2 h / Reflux

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.75 h / -20 - -17 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / Inert atmosphere; Cooling with ice-water

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.75 h / 20 °C / Inert atmosphere

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 6 h / 65 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Horner-Wadsworth-Emmons Olefination / 1.2: Horner-Wadsworth-Emmons Olefination;