Technology Process of ethyl [4-[3,3-di(5-bromothiophen-2-yl)allylsulfanyl]-2-methylphenoxy]acetate
There total 5 articles about ethyl [4-[3,3-di(5-bromothiophen-2-yl)allylsulfanyl]-2-methylphenoxy]acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,3-di(5-bromothiophen-2-yl)allyl alcohol;
With
carbon tetrabromide; triphenylphosphine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
With
water;
In
dichloromethane;
for 0.25h;
ethyl [(4-mercapto-2-methylphenyl)oxy]acetate;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 3.75h;
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 3.75h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.75 h / -20 - -17 °C / Inert atmosphere
2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.75 h / Inert atmosphere; Cooling with ice-water
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.75 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; lithium aluminium tetrahydride; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
diethyl ether; dichloromethane;
