N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

Base Information

Chemical Name:N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide
CAS No.:1371589-14-8
Molecular Formula:C₁₇H₂₆F₃NO₃Si
Molecular Weight:377.479
Hs Code.:

Synonyms:N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

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Chemical Property of N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

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Technology Process of N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

There total 4 articles about N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-99-6
3,3,3-Trifluoropropionic acid

: 1371589-13-7
2-((tert-butyldimethylsilyloxy)methyl)-4-methoxy aniline

: 1371589-14-8
N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 1371589-14-8
N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / tetrahydrofuran / 4 h / Reflux

1.2: 3.5 h / 0 - 30 °C

1.3: pH 8 / Cooling with ice

2.1: 1H-imidazole / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 - 30 °C

2.2: Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 30 °C / 2068.65 Torr

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; thionyl chloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 879-55-0
(5-methoxy-2'-nitrophenyl)methanol

: 1371589-14-8
N-(2-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 - 30 °C

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 30 °C / 2068.65 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;