(6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine

Base Information

• Chemical Name: (6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine
• CAS No.: 131266-56-3
• Molecular Formula: C₁₆H₁₄N₂OS
• Molecular Weight: 282.366
• Mol file: 131266-56-3.mol

Synonyms:(6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine

Chemical Property of (6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine

There total 1 articles about (6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Amino-6-ethoxybenzothiazole (94-45-1) + benzaldehyde (100-52-7) → (6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine (131266-56-3)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1515/HC.2005.11.6.527

Reference yield: 68.0%

(6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine (131266-56-3) + ammonium thiocyanate (1147550-11-5) → 7-ethoxy-2-phenyl-2,3-dihydro-9-thia-1,3,4a-triaza-fluorene-4-thione (889885-41-0)

Guidance literature:

In 1,4-dioxane; for 6h; Heating;

DOI:10.1515/HC.2005.11.6.527

Reference yield:

(6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine (131266-56-3) + homophthalic anhydride (703-59-3) + diazomethyl-trimethyl-silane (18107-18-1) → methyl (3R,4R)-2-(6-ethoxybenzo[d]thiazol-2-yl)-1-oxo-3-phenyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylate + methyl 2-(6-ethoxybenzo[d]thiazol-2-yl)-1-oxo-3-phenyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylate

Guidance literature:

(6-Ethoxy-benzothiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine; homophthalic anhydride; With (R_a)-1-(2-(((Z)-1-benzyl-2-oxoindolin-3-ylidene)(1H-indol-2-yl)methyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)thiourea; In acetone; at -60 ℃; for 12h; Schlenk technique;

diazomethyl-trimethyl-silane; In methanol; acetone; at -60 ℃; for 0.166667h; Overall yield = 86 percent; Overall yield = 39.4 mg; stereoselective reaction; Schlenk technique;

DOI:10.1002/anie.202112226

upstream raw materials:

2-Amino-6-ethoxybenzothiazole

benzaldehyde

Downstream raw materials:

7-ethoxy-2-phenyl-2,3-dihydro-9-thia-1,3,4a-triaza-fluorene-4-thione