(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Base Information

Chemical Name:(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol
CAS No.:1416557-26-0
Molecular Formula:C₁₅H₂₁FO
Molecular Weight:236.33
Hs Code.:

Synonyms:(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Suppliers and Price of (R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Chemical Property:

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Technology Process of (R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

There total 8 articles about (R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1416557-25-9
(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

: 1416557-26-0
(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Guidance literature:: (2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 2979-10-4
ethyl 2,2-dimethyl-6-oxocyclohexane-1-carboxylate

: 1416557-26-0
(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / diethyl ether; mineral oil / 0.5 h / -20 °C

1.2: 1 h / -30 - 20 °C

2.1: triethylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 60 °C / Inert atmosphere

3.1: hydrogen / methanol / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 2 h / -78 °C

6.2: 20 °C

7.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

8.2: 20 °C

With triethylsilane; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1257045-68-3
ethyl {6,6-dimethyl-2-(trifluoromethanesulfonyloxy)cyclohexene-1-yl}carboxylate

: 1416557-26-0
(R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 60 °C / Inert atmosphere

2.1: hydrogen / methanol / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere

3.2: 20 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 2 h / -78 °C

5.2: 20 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

7.2: 20 °C

With triethylsilane; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;