(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

Base Information

Chemical Name:(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone
CAS No.:1416557-25-9
Molecular Formula:C₁₅H₁₉FO
Molecular Weight:234.314
Hs Code.:

Synonyms:(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

Chemical Property:

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Technology Process of (2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

There total 7 articles about (2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (S)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol

: 1416557-25-9
(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 2979-10-4
ethyl 2,2-dimethyl-6-oxocyclohexane-1-carboxylate

: 1416557-25-9
(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / diethyl ether; mineral oil / 0.5 h / -20 °C

1.2: 1 h / -30 - 20 °C

2.1: triethylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 60 °C / Inert atmosphere

3.1: hydrogen / methanol / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 2 h / -78 °C

6.2: 20 °C

7.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C / Inert atmosphere

With triethylsilane; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1257045-68-3
ethyl {6,6-dimethyl-2-(trifluoromethanesulfonyloxy)cyclohexene-1-yl}carboxylate

: 1416557-25-9
(2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 60 °C / Inert atmosphere

2.1: hydrogen / methanol / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere

3.2: 20 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 2 h / -78 °C

5.2: 20 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 0 °C / Inert atmosphere

With triethylsilane; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;