(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester
CAS No.:107492-14-8
Molecular Formula:C₂₅H₃₄NO₆P
Molecular Weight:475.522
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

There total 2 articles about (S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 107492-14-8
(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / potassium carbonate / dimethylformamide / 2 h / Ambient temperature

2: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 107492-32-0
(S)-2-hydroxy-6<<(phenylmethoxy)carbonyl>amino>hexanoic acid methyl ester

: 107492-14-8
(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 0.666667h; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield:

: 107492-14-8
(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester

: 107492-21-7
(S)-N-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-N-cyclohexylglycine

Guidance literature:: Multi-step reaction with 4 steps

1: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

2: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

3: 52 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

4: H₂ / 20percent Pd/C / methanol / 3 h

With sodium hydroxide; sodium periodate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028