tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

Base Information

Chemical Name:tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate
CAS No.:302790-51-8
Molecular Formula:C₂₃H₂₇FN₂O₅
Molecular Weight:430.476
Hs Code.:

Synonyms:tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

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Chemical Property of tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

Chemical Property:

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Technology Process of tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

There total 4 articles about tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 171050-01-4
tert-butyl 4-fluoro-3-(methylaminomethyl)benzoate

: 302790-51-8
tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jm020050+

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 302790-51-8
tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / tetrahydrofuran / 4.25 h / -78 - 20 °C

2.1: NBS; benzoyl peroxide / CCl₄ / 24 h / Heating; irradiation

2.2: 43 percent / tetrahydrofuran; H₂O / 18 h / 20 °C

3.1: 100 percent / HOBt*H₂O; DCC / dimethylformamide; CH₂Cl₂ / 16 h

With N-Bromosuccinimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020050+

Reference yield:

: 82297-89-0
(4-fluoro-3-methyl)phenylmagnesium bromide

: 302790-51-8
tert-butyl 3-[[[2-(benzyloxycarbonylamino)acetyl]methylamino]methyl]-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / tetrahydrofuran / 4.25 h / -78 - 20 °C

2.1: NBS; benzoyl peroxide / CCl₄ / 24 h / Heating; irradiation

2.2: 43 percent / tetrahydrofuran; H₂O / 18 h / 20 °C

3.1: 100 percent / HOBt*H₂O; DCC / dimethylformamide; CH₂Cl₂ / 16 h

With N-Bromosuccinimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020050+