2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

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Chemical Name:2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
CAS No.:1246182-33-1
Molecular Formula:C₃₇H₃₄ClN₃O₇
Molecular Weight:668.146
Hs Code.:

Synonyms:2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

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Chemical Property of 2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

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Technology Process of 2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

There total 3 articles about 2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1051372-99-6
6-(N,N-dimethylamino)-2-[2-(2-hydroxyethoxy)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 1246182-33-1
2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1007/s00706-010-0337-x

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 1246182-33-1
2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide / 1.5 h / Reflux

2: ethanol / 1.5 h / Inert atmosphere; Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 48 h / 20 °C / Inert atmosphere

With dmap; copper(ll) sulfate pentahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1007/s00706-010-0337-x

Reference yield:

: 77976-79-5
4-(N,N-dimethylamino)-1,8-naphthalic anhydride

: 1246182-33-1
2-{2-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]ethoxy}ethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1.5 h / Inert atmosphere; Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 48 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; chloroform;
DOI:10.1007/s00706-010-0337-x