10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

Base Information

Chemical Name:10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid
CAS No.:207670-44-8
Molecular Formula:C₃₄H₂₇N₃O₅
Molecular Weight:557.605
Hs Code.:

Synonyms:10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

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Chemical Property of 10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

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Technology Process of 10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

There total 1 articles about 10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207670-43-7
N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

: 207670-44-8
10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

Guidance literature:: N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide; With sodium hydroxide; water; In tetrahydrofuran; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 207670-44-8
10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

: 207670-43-7
N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 3.5 h / 20 °C

2: trifluoroacetyl chloride / dichloromethane / 4 h / 0 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetyl chloride; dmap; In dichloromethane;

Reference yield:

: 207670-44-8
10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

: 207670-33-5
10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxy-benzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid-1,1-dimethylhydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 3.5 h / 20 °C

2: trifluoroacetyl chloride / dichloromethane / 4 h / 0 - 20 °C

3: dichloromethane / 0.42 h / 20 °C / Heating / reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetyl chloride; dmap; In dichloromethane;