N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

Base Information

Chemical Name:N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide
CAS No.:207670-43-7
Molecular Formula:C₃₅H₂₆Cl₃N₃O₄
Molecular Weight:658.968
Hs Code.:

Synonyms:N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

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Chemical Property of N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

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Technology Process of N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

There total 10 articles about N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 207670-32-4
10-(4-[(biphenyl-2-carbonyl)amino]-2-methoxy-benzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid-piperazine-N-methyl amide

: 207670-43-7
N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

Guidance literature:: With trifluoroacetyl chloride; In dichloromethane; at 0 - 20 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 2597-56-0
4-nitro-o-anisic acid

: 207670-43-7
N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 16 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 2585.81 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

4: sodium hydroxide; water / methanol / 2 h / Heating / reflux

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Heating / reflux

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

7: dichloromethane / 4 h / 0 - 20 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;

Reference yield:

: 207670-44-8
10-(4-[(biphenyl-2-carbonyl)-amino]-2-methoxybenzoyl)-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-3-carboxylic acid

: 207670-43-7
N-[[5-[3-trichloromethylcarbonyl]-[5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-10(11H)-yl]carbonyl]-2-methoxyphenyl]-2-phenylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 3.5 h / 20 °C

2: trifluoroacetyl chloride / dichloromethane / 4 h / 0 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetyl chloride; dmap; In dichloromethane;