N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

Base Information

Chemical Name:N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide
CAS No.:246235-98-3
Molecular Formula:C₂₆H₂₈F₂N₂O₂
Molecular Weight:438.517
Hs Code.:

<i>N</i>-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

Synonyms:N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

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Chemical Property of N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

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Technology Process of N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

There total 3 articles about N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 53915-75-6
1-[bis(4-fluorophenyl)methoxy]-2-bromoethane

: 191796-95-9
N-(phenylacetyl)-1,3-propanediamine

: 246235-98-3
N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm990161h

Reference yield:

: 365-24-2
4,4'-difluorobenzhydryl alcohol

: 246235-98-3
N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂SO₄ / toluene / 6 h / Heating

2: 85 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide; toluene; 1: Etherification / 2: Alkylation;
DOI:10.1021/jm990161h

Reference yield:

: 103-80-0
phenylacetyl chloride

: 246235-98-3
N-(3-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethylamino}-propyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 85 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;
DOI:10.1021/jm990161h