4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

Base Information

Chemical Name:4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone
CAS No.:228553-02-4
Molecular Formula:C₂₀H₂₄O₃
Molecular Weight:312.409
Hs Code.:

Synonyms:4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

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Chemical Property of 4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

Chemical Property:

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Technology Process of 4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

There total 4 articles about 4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 228553-01-3
4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohex-2-enone

: 228553-02-4
4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

Guidance literature:: With hydrogen; Wilkinson's catalyst; In benzene; for 6h; under 1520 Torr; Ambient temperature;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 15971-29-6
4-methoxy-1-naphthaldehyde

: 228553-02-4
4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / 2.) 10 percent hydrochloric acid / tetrahydrofuran / Ambient temperature; 1.) 16 h; 2.) 2 d

2: 88 percent / lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

3: 82 percent / 1.) lithium aluminum hydride; 2.) aq. HCl / tetrahydrofuran / 0.17 h / 0 °C

4: 100 percent / hydrogen / (Ph₃P)3RhCl / benzene / 6 h / 1520 Torr / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; lithium diisopropyl amide; Wilkinson's catalyst; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 228552-89-4
(4-methoxy-naphthalen-1-yl)acetaldehyde

: 228553-02-4
4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

2: 82 percent / 1.) lithium aluminum hydride; 2.) aq. HCl / tetrahydrofuran / 0.17 h / 0 °C

3: 100 percent / hydrogen / (Ph₃P)3RhCl / benzene / 6 h / 1520 Torr / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; lithium diisopropyl amide; Wilkinson's catalyst; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(99)00658-9