5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester
CAS No.:228553-03-5
Molecular Formula:C₂₄H₂₈O₇
Molecular Weight:428.482
Hs Code.:

Synonyms:5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

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Technology Process of 5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

There total 5 articles about 5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 616-38-6
carbonic acid dimethyl ester

: 228553-02-4
4-[1-hydroxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-4-methyl-cyclohexanone

: 228553-03-5
5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With sodium hydride; for 0.5h; Heating;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 15971-29-6
4-methoxy-1-naphthaldehyde

: 228553-03-5
5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / 2.) 10 percent hydrochloric acid / tetrahydrofuran / Ambient temperature; 1.) 16 h; 2.) 2 d

2: 88 percent / lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

3: 82 percent / 1.) lithium aluminum hydride; 2.) aq. HCl / tetrahydrofuran / 0.17 h / 0 °C

4: 100 percent / hydrogen / (Ph₃P)3RhCl / benzene / 6 h / 1520 Torr / Ambient temperature

5: 75 percent / sodium hydride / 0.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; lithium diisopropyl amide; Wilkinson's catalyst; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(99)00658-9

Reference yield:

: 228552-89-4
(4-methoxy-naphthalen-1-yl)acetaldehyde

: 228553-03-5
5-[1-methoxycarbonyloxy-2-(4-methoxy-naphthalen-1-yl)-ethyl]-5-methyl-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

2: 82 percent / 1.) lithium aluminum hydride; 2.) aq. HCl / tetrahydrofuran / 0.17 h / 0 °C

3: 100 percent / hydrogen / (Ph₃P)3RhCl / benzene / 6 h / 1520 Torr / Ambient temperature

4: 75 percent / sodium hydride / 0.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; lithium diisopropyl amide; Wilkinson's catalyst; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(99)00658-9