2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

Base Information

Chemical Name:2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide
CAS No.:158664-24-5
Molecular Formula:C₂₃H₃₂N₂O₂S
Molecular Weight:400.585
Hs Code.:

Synonyms:2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

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Chemical Property of 2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

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Technology Process of 2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

There total 4 articles about 2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 6668-27-5,23844-66-8,42070-94-0,68906-26-3
2-methyl-1-phenyl-propylamine

: 139343-81-0
(S_(S)R)-(+)-3-methyl-2-pivaloyl-2,3-dihydroisothiazole 1-oxide

: 158664-24-5
2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

: 2,2-Dimethyl-N-{(R)-1-[2-((R)-(S)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) r.t., 30 min, 2.) r.t., 30 min;
DOI:10.1039/p19960000691

Reference yield:

: (R_(S),R)-2-<1-(tert-Butylcarbonylamino)ethyl>-N-(2-methyl-1-phenylpropylidene)benzenesulfinamide

: 158664-24-5
2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

: 2,2-Dimethyl-N-{(R)-1-[2-((R)-(S)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -23 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)77091-2

Reference yield:

: 100-47-0
benzonitrile

: 158664-24-5
2,2-Dimethyl-N-{(R)-1-[2-((R)-(R)-2-methyl-1-phenyl-propylsulfinamoyl)-phenyl]-ethyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuCl / 1.) THF, reflux, 3 h, 2.) r.t., 30 min

2: DIBAL, ZnBr₂ / tetrahydrofuran; hexane / Ambient temperature

With diisobutylaluminium hydride; copper(l) chloride; zinc dibromide; In tetrahydrofuran; hexane;
DOI:10.1039/p19960000691