Technology Process of 6-amino-5-bromo-2-(2,4-difluorophenyl)-N-methylbenzofuran-3-carboxamide
There total 4 articles about 6-amino-5-bromo-2-(2,4-difluorophenyl)-N-methylbenzofuran-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate;
In
N,N-dimethyl-formamide;
at 15 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrafluoroboric acid diethyl ether complex / dichloromethane / 38 °C
2.1: nitric acid / chloroform / 2.5 h / -20 - 0 °C
3.1: ammonium chloride; iron / methanol; water; tetrahydrofuran / 3 h / Reflux
4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C
5.2: 2 h
6.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
6.2: 1 h / -78 °C
7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / N,N-dimethyl-formamide / 3 h / 15 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; tetrafluoroboric acid diethyl ether complex; water; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
7.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: nitric acid / chloroform / 2.5 h / -20 - 0 °C
2.1: ammonium chloride; iron / methanol; water; tetrahydrofuran / 3 h / Reflux
3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C
4.2: 2 h
5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
5.2: 1 h / -78 °C
6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / N,N-dimethyl-formamide / 3 h / 15 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;
6.1: |Suzuki Coupling;
