1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

Base Information

Chemical Name:1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone
CAS No.:1427054-96-3
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

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Chemical Property of 1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

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Technology Process of 1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

There total 3 articles about 1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1427054-93-0
1-benzyl-5-(2-propynyl)-2-pyrrolidinone

: 200060-21-5
2-iodo-3’,4,4’,5-tetramethoxybiphenyl

: 1427054-96-3
1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

Guidance literature:: With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In toluene; at 50 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2013.02.014

Reference yield:

: 1-benzyl-5-hydroxy-5-(2-propynyl)pyrrolidin-2-one

: 1427054-96-3
1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: bromophenol blue; sodium cyanoborohydride; hydrogenchloride / methanol / 1.5 h / 20 °C / pH Ca_. 3

2: piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 18 h / 50 °C / Inert atmosphere

With piperidine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium cyanoborohydride; bromophenol blue; In methanol; toluene; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.02.014

Reference yield:

: 2142-06-5
1-(phenylmethyl)-2,5-pyrrolidinedione

: 1427054-96-3
1-benzyl-5-[3-(4,4',5,5'-tetramethoxybiphenyl-2-yl)-2-propynyl]-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: lead(II) bromide; zinc / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2: bromophenol blue; sodium cyanoborohydride; hydrogenchloride / methanol / 1.5 h / 20 °C / pH Ca_. 3

3: piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 18 h / 50 °C / Inert atmosphere

With piperidine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lead(II) bromide; sodium cyanoborohydride; bromophenol blue; zinc; In tetrahydrofuran; methanol; toluene; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.02.014