2142-06-5

Basic information

• Product Name: 1-benzylpyrrolidine-2,5-dione
• Synonyms: 1-benzylpyrrolidine-2,5-dione;N-Benzylsuccinimide
• CAS NO: 2142-06-5
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.213
• Mol File: 2142-06-5.mol
• Article Data: 82

Chemical Properties

• Melting Point: 103°C
• Boiling Point: 324.47°C (rough estimate)
• Flash Point: 194.1°C
• Appearance: /
• Density: 1.1596 (rough estimate)
• Vapor Pressure: 1.97E-06mmHg at 25°C
• Refractive Index: 1.5012 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.37±0.20(Predicted)
• CAS DataBase Reference: 1-benzylpyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylpyrrolidine-2,5-dione(2142-06-5)
• EPA Substance Registry System: 1-benzylpyrrolidine-2,5-dione(2142-06-5)

Safety Data

• Hazardous Substances Data: 2142-06-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzylpyrrolidine-2,5-dione is used as an intermediate in organic synthesis for the production of pharmaceuticals. Its role in the synthesis of biologically active compounds makes it valuable in the development of new medications.
Used in Agrochemical Industry:
1-Benzylpyrrolidine-2,5-dione is also utilized in the field of agrochemicals, where it serves as an intermediate in the synthesis of various compounds that can be used in agricultural applications.
Used in Drug Development:
Due to its anti-inflammatory and analgesic properties, 1-benzylpyrrolidine-2,5-dione is used as a candidate for further drug development, potentially leading to new treatments for pain and inflammation-related conditions.

InChI:InChI=1/C11H11NO2/c13-10-6-7-11(14)12(10)8-9-4-2-1-3-5-9/h1-5H,6-8H2

Upstream product

• 108-30-5 succinic acid anhydride 
• 100-46-9 benzylamine 
• 54553-14-9 succinic acid N-(chloromethyl)imide 
• 71-43-2 benzene 
• 128-09-6 N-chloro-succinimide 
• 108-88-3 toluene 
• 128-08-5 N-Bromosuccinimide 
• 1028903-71-0 N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione 
• 75172-31-5 (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione 
• 100-39-0 benzyl bromide 
• 123-56-8 Succinimide 
• 110-63-4 Butane-1,4-diol 
• 100-47-0 benzonitrile 
• 108-31-6 maleic anhydride 

Downstream Products

• 929037-56-9 4-benzyl-4-azaspiro[2.4]heptane-5-one 
• 1264932-17-3 ethyl 10-benzyl-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo-[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate 
• 159757-34-3 1-benzyl-5-hydroxy-5-(2-phenylethyl)pyrrolidin-2-one 
• 159757-35-4 1-benzyl-5-hydroxy-5-(3-phenylpropyl)pyrrolidin-2-one 
• 587854-63-5 1-benzyl-5-hydroxy-5-[3-(3',4'-methylenedioxyphenyl)propyl]pyrrolidin-2-one 
• 587854-62-4 1-benzyl-5-hydroxy-5-[2-(3',4'-methylenedioxyphenyl)ethyl]pyrrolidin-2-one 
• 353796-55-1 1-benzyl-5-hydroxy-5-vinylpyrrolidin-2-one 
• 302777-37-3 1-benzyl-5-hydroxy-5-(3-trimethylsilylprop-2-ynynl)-pyrrolidin-2-one 
• 80301-56-0 1-(4′-nitrobenzyl)pyrrolidine-2,5-dione 

Relevant articles and documents

Iridium-catalyzed double incorporation reaction of N-benzylmaleimide to styrene via ortho-C-H bond activation, initiated by precoordination of the double bond of styrene to iridium

Reaction of styrene with N-benzylmaleimide in the presence of [IrCl(cod)]2 (5 mol %) and bpy (10 mol %) in an autoclave (1 MPa of Ar) at 150°C for 18 h stereoselectively led to the formation of a new cyclic product. The structure of the product suggests that a novel iridium-catalyzed double incorporation reaction takes place via a metallacyclopentane formed after ortho-C-H activation.

Preparation method of N-(aryl/heteroaryl) alkyl-diamide

The invention relates to a preparation method of N-(aryl/heteroaryl)alkyl- diamide, which comprises the following steps: under the protection of nitrogen, sequentially adding transition metal, phosphine or nitrogen ligand, cocatalyst, alkali, solvent, Nhalogenated cyclodiamide, alkyl aromatic ring or alkyl heteroaromatic ring compound into a reaction container, carrying out oxidative amination reaction at 80-140 DEG C, and till the reaction concludes after 6-48 hours, evaporating and drying a solvent and carrying out column chromatography separation to obtain an N (aryl/heteroaryl) alkyl diamide compound. The invention is simple in synthesis process, mild in reaction condition, high in yield and easy to industrialize.

Photoredox/Cobalt-Catalyzed C(sp3)-H Bond Functionalization toward Phenanthrene Skeletons with Hydrogen Evolution

The first example of photoredox strategy for synthesis of phenanthrene skeletons through C(sp3)-H functionalization under external oxidant-free conditions is achieved. This transformation relies on the keto-enol tautomerism of 1,3 dicarbonyl moiety, i.e., the enol form of 1,3-dicarbonyl derivatives with relatively lower oxidation potential can be activated by the excited acridinium photocatalyst. The electron and proton eliminated from the substrate are immediately captured by a cobaloxime catalyst to exclusively afford a-carbonyl radical for highly substituted 10-phenanthrenols in good to excellent yields.

NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL UREA 6,7-DIHYDRO-4H-PYRAZOLO[4,3-C]PYRIDINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for mating the compounds.

NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL PHENYL AND PYRIDYL UREAS ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

N -Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N -chlorosuccinimide

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with commercially available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theoretical analysis indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.