N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

Base Information

Chemical Name:N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM
CAS No.:383910-55-2
Molecular Formula:C₃₄H₄₈N₂O₁₀Si
Molecular Weight:672.848
Hs Code.:

Synonyms:N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

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Chemical Property of N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

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Technology Process of N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

There total 3 articles about N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 383910-54-1
N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid

: 383910-55-2
N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

Guidance literature:: With dmap; Isopropenyl chloroformate; triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jo0105991

Reference yield:

: 383910-53-0
methyl N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylate

: 383910-55-2
N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiOH*H₂O / tetrahydrofuran; methanol / 18 h / 0 - 20 °C

2: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

With dmap; lithium hydroxide; Isopropenyl chloroformate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo0105991

Reference yield:

: 383910-52-9
methyl N-Cbz-L-1,2,3,4-tetrahydro-7-methoxy-6,8-di-iodoisoquinoline-3-carboxylate

: 383910-55-2
N-Cbz-L-3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline-O-Boc-threonine-OSEM

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaBH₄; CuCl / methanol / 0 °C

2: 97 percent / LiOH*H₂O / tetrahydrofuran; methanol / 18 h / 0 - 20 °C

3: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; Isopropenyl chloroformate; triethylamine; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo0105991