trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Chemical Name:trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester
CAS No.:887468-73-7
Molecular Formula:C₁₅H₉F₃N₂O₆S
Molecular Weight:402.307
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Chemical Property of trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Technology Process of trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

There total 9 articles about trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 887468-56-6
trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

: 887468-73-7
trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 168h;
DOI:10.1021/jm0509389

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 887468-73-7
trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / tetrahydrofuran / 0 - 20 °C

2.1: 59 percent / DMAP / N,N-dimethyl-acetamide / 24 h / 110 °C

3.1: 55.1 g / 4 h / Heating

4.1: 48 percent / LiCl / dimethylformamide / 2.5 h / 135 °C

5.1: NaH / dimethylformamide / 1 h / 0 - 20 °C

5.2: 85 percent / dimethylformamide / 1 h / 0 - 20 °C

6.1: 93 percent / BBr₃ / CH₂Cl₂ / 168 h / 20 °C

With dmap; boron tribromide; sodium hydride; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm0509389

Reference yield:

: 628687-05-8
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone

: 887468-73-7
trifluoro-methanesulfonic acid 7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 0 - 20 °C

1.2: 85 percent / dimethylformamide / 1 h / 0 - 20 °C

2.1: 93 percent / BBr₃ / CH₂Cl₂ / 168 h / 20 °C

With boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0509389